Prostatic Artery Embolization with 250-μm Spherical Polyzene-Coated Hydrogel Microspheres for Lower Urinary Tract Symptoms with Follow-up MR Imaging
Figure. (a) Posterior–anterior view of the left hemiprostate after application of contrast material. The microcatheter is placed above the bifurcation of the left prostatic artery into a central branch (vertical arrow) and a lateral branch (horizontal arrow). (b) Image after PAE with 250-μm microspheres.
This manuscript presents the results of a specific embolic agent, 250um Polyzene-coated hydrogel microspheres (Embozene; Boston Scientific), on PAE performed in a limited cohort of patients with symptomatic BPH. Effectiveness and safety results were comparable to the current literature. As PAE is becoming a common therapeutic approach in this patient population, the question of which embolic agent is the most appropriate starts to emerge. Recent meta-analysis including studies that used different types of particulate agents showed better clinical outcomes with smaller PVA (50-100um). However, to better answer this question large randomized control trials would be required. For now any additional evidence on different agents are welcomed to help interventionalists decide which material to use. Finally, defining predictor factors for better clinical outcomes on imaging can be extremely helpful, but this was not possible in the present study likely due to the small sample size, which is a limitation. Further investigation could aim to define predictor factors on pre-procedure imaging. These potential findings could really impact the decision making process and clinical management.
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Franiel T, Aschenbach R, Trupp S, et al. Prostatic artery embolization with 250-μm spherical polyzene-coated hydrogel microspheres for lower urinary tract symptoms with follow-up MR imaging. J Vasc Interv Radiol. 2018; 29: 1127-1137.
Ricardo Yamada, MD
Department of Radiology
Division of Vascular and Interventional Radiology
Medical University of South Carolina