The purpose of this study was to perform a meta-analysis and systematic review of the clinical efficacy and safety of radiofrequency ablation in the treatment of intrahepatic cholangiocarcinoma. Authors collected data from Ovid MEDLINE and EMBASE database. Seven out of 144 articles comprising 84 total patients were selected based on strict exclusion criteria. Technical success rate for radiofrequency ablation ranges from 66-100 % with different approaches like ultrasound guided with conscious sedation or intraoperative with general anesthesia. The pooled 1-year, 3-year, and 5-year survival rates were 82% (95% CI, 72%–90%), 47%(95% CI, 28%–65%), and 24% (95% CI, 11%–40%) respectively. While the overall median survival is superior when compared with other arterial-based locoregional therapies, comparison is difficult given a significantly decreased incidence of extrahepatic disease in the present analysis.
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Citation: Han, K. et al. Radiofrequency Ablation in the Treatment of Unresectable Intrahepatic Cholangiocarcinoma: Systematic Review and Meta-Analysis. Journal of Vascular and Interventional Radiology 26, 943–948 (2015).
Author: Ali Rahmat, MD. Yale University Radiology Resident.