Their study found a 30% reduction in the ghrelin-immunoreactive cell density in the gastric fundus of pigs that underwent bariatric embolization via the gastric artery with 4-6 mL of diluted 40-µm calibrated microspheres compared to 6 control swine treated with normal saline. A trend toward increased stomach fibrosis (P = .07) was also found in the treated swine, as well as stomach ulcers in half the treatment subset.
This study sheds light upon the impact of bariatric embolization on stomach hormone production and supports the scientific basis for bariatric embolization as a minimally invasive weight loss therapy. The authors are currently planning to begin the first US clinical trial of bariatric embolization on humans this summer at Johns Hopkins Hospital.
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Citation: Paxton, B. E. et al. Histopathologic and Immunohistochemical Sequelae of Bariatric Embolization in a Porcine Model. Journal of Vascular and Interventional Radiology 25, 455–461 (2014).
Post author: Austin Bourgeois, MD