JVIR twitter

Thursday, February 21, 2019

In Vitro Evaluation of the Polymerization Properties of N-Butyl Cyanoacrylate/Iodized Oil Mixtures for Lymphatic Interventions 


Clinical question
What are the properties of N-Butyl cyanoacrylate (NBCA)-iodized oil mixtures which affect polymerization in an in vitro model?

Take-away point
Polymerization time of NBCA/iodized oil in lymphatic fluid is prolonged by increasing iodized oil and triglyceride (TG) concentrations.

Reference
Kuetting, Daniel, et al. In Vitro Evaluation of the Polymerization Properties of N-Butyl Cyanoacrylate/Iodized Oil Mixtures for Lymphatic Interventions. Journal of Vascular and Interventional Radiology. January, 2019. Volume 30, Issue 1, 110–117.

Click here for abstract

Study design: Translational

Funding source: Self-funded or unfunded

Setting: Single institution

Summary


The polymerization characteristics of NBCA/iodized oil mixtures have been studied extensively in the vascular system and, therefore, use of glue in the vascular system is reliable and predictable. However, factors influencing NBCA/iodized oil polymerization within the lymphatic system, which differs from the vascular system in both flow and fluid composition, is not as well studied.

In order to elucidate factors affecting polymerization of NBCA/iodized oil in the lymphatic system, the authors of this study looked at varying ratios of NBCA/iodized oil in lymphatic fluid samples which differed by triglyceride content. NBCA/iodized oil mixture ratios from 1:0 to 1:7 were evaluated in 8 different lymphatic fluid samples which, apart from triglyceride content, did not differ significantly in total protein, leukocytes, sodium, potassium, calcium, or chloride levels. Fluid samples were designated as low TGs (< 50 mg/dL), n=3;
Medium TGs (100–400 mg/dL), n=3; High TGs (> 700 mg/dL), n=2. They performed a “static analysis” of polymerization time by dropping different NBCA/oil mixtures in the various lymphatic samples and evaluating time to polymerization and total polymerization time using a high-speed camera. “Dynamic analysis” of polymerization time was performed by injection of different NBCA/oil mixtures into a dynamic flow model transfusion tube containing microcoils with a constant lymph flow rate. The total polymerization time was found to be dependent on the ratio of iodized oil and the concentration of TGs. In dynamic experiments, this difference in polymerization time was found to be less pronounced but in high TG samples, polymerization took significantly longer (between 43 s at a 1:1 ratio and 467 s at a 1:7 ratio). Occlusion with a 1:7 mixture was achieved in only 1 attempt and failed in the other 4 experiments.



Commentary


Using a clever dynamic flow model, the authors were able to determine that polymerization time of NBCA/iodized oil in the lymphatic system is dependent on both the NBCA/iodized oil ratio in addition to the TG content of lymphatic fluid. This is important because, until now, the behavior of glue was only best understood in the vascular system. The use of glue, however, is important in the treatment of chylous leaks as lymphatic fluid does not have the same clotting ability of blood. Knowledge of glue polymerization characteristics in the lymphatic system is important to avoid complications. Additionally, a priori knowledge of TG content in a patient for whom thoracic duct embolization is planned may warrant initiation of nutritional therapy to mitigate the risk of treatment failure. All in all, this work represents an important step toward better understanding the optimal use of one of our increasingly-utilized embolic agents in the lymphatic system.

Post Author:
Zagum Bhatti, MD
Assistant Professor
Department of Radiology, Interventional Radiology Division
University of Texas Health Science Center at Houston, Houston, TX
@ZagumBhatti

1 comment:

  1. ADD DR PERFECT ON WHATSAPP +1 (256)-251-3614 AND GET A CURE TO ANY TYPE OF DISEASES AND VIRUS

    I'm so happy and excited to give my testimony of how I was cure of herpes virus. I'm Karen Wilson from Paris France I was diagnosed with herpes virus for 6 years, I took every drugs prescribed to me by the doctors but there was no positive result, so I decided to try if I can find a cure for my herpes online and I saw different people's comments on how Dr Perfect helped them to cure their diseases and viruses I message him urgently on WhatsApp it's didn't take long he replied my message and we talked on how I can get the cure and he told me he will send the cure to me, in four days time the cure was delivered to my house and he gave me instruction on how I will use it, 17 days later there was no sign of herpes in my body then I went for test and the doctor told me he couldn't find any sign of herpes virus in my blood. Dr Perfect herbal cure is the best don't think because he cured me of herpes virus and you are diagnosed with Hepatitis or other virus he can't cure you, Dr Perfect can cure all types of diseases and virus. If you need a cure for your disease and virus WhatsApp him +1 (256)-251-3614 if you are not on WhatsApp email him at solutiontoallproblems1@gmail.com

    ReplyDelete