JVIR twitter

Tuesday, November 4, 2014

Covered verses uncovered stents for malignant common bile duct obstruction, which lasts longer?

The often taught convention that covered biliary stents stay open longer than their bare relatives may not be true. Researchers from Seoul, South Korea are challenging this, finding that uncovered stents had significantly longer patency in their subjects. Although limited by a small sample size of 20 patients in each arm, this prospective randomized study found that the uncovered stents had a mean patency of 413 days, double that of the covered ones at 208 days.

Covered stents were always thought to have better patency because of their ability to avoid tumor ingrowth, a theory that was previously supported by several randomized studies. After finding the opposite, the authors of this study theorize that pores on the surface of the covered stent act to promote bacterial colonization and biofilm development, in turn leading to slower bile flow. Nevertheless, the authors found no survival benefit for either stent.


Click here to see the full abstract




Kaplan-Meier graph showing cumulative stent patency. Cumulative stent patency was significantly higher in the uncovered metallic stent versus the covered metallic stent group (P = .041, log-rank test).




Stent occlusion by sludge. (a) Percutaneous cholangiography performed after 10 mm × 80 mm Niti-S covered stent placement. The stent is not yet fully dilated. (b) Cholangiography performed 2 months after stent placement showed multiple filling defects (arrows), suggesting debris. Debris and food material were confirmed by saline irrigation.


Citation: Lee, S. J. et al. Comparison of the Efficacy of Covered versus Uncovered Metallic Stents in Treating Inoperable Malignant Common Bile Duct Obstruction: A Randomized Trial. Journal of Vascular and Interventional Radiology (2014). doi:doi: 10.1016/j.jvir.2014.05.021


Post author: Amish Patel, MD

1 comment:

  1. Dr. Sam has really made me so much believe in him by getting me cured with his herbal treatment. i really appreciate you Dr.Sam for bringing back happiness to my life again. thanks you so much,friends join me to thank him for what he has actually done for me i pray to you all for a good life and good health, and most especially to you Dr. Sam THANKS.

    I have been suffering from (HERPES SIMPLEX VIRUS) disease for the past four years and had constant pain, especially in my knees. During the first year,I had faith in God that i would be healed someday.This disease started circulating all over my body and i have been taking treatment from my doctor, few months ago i came on search on the internet if i could get any information concerning the cure of this disease, on my search i saw a testimony of someone who has been healed from (HERPES SIMPLEX VIRUS) by this Man Dr Sam and she drop the email address of this man and advise we should contact him for any sickness that he would be of help, so i wrote to Dr. Sam telling him about my (HERPES Virus) well after all the procedures and remedy given to me by this man few weeks later i started experiencing changes all over me. I am now here to testify that i am not longer a herpes patient, I have experience a total transformation in my life,for all herpes patients get your herbal medicine to cure your sickness. And there has being rapid improvement in my health, I no longer feel pains and I wake up each morning feeling revived. So friends my advise is if you have such sickness or any other at all,you can contact him. {supremecurehome@gmail.com} Wbesite: http://www.supremecurehome.blogspot.com

    CANCER
    EPILEPSY.
    GENPILENCIN.
    HIV AIDS.
    COPD
    DIABETICS
    STROKE.
    EXPANDS OF PENIS BREAST
    H.P.V TYPE 1 TYPE 2 TYPE 3 AND TYPE 4. TYPE 5.
    HUMAN PAPAILOMA VIRUS.
    HERPES.
    SYPHILIS.
    HEPATITIS A B and C.

    Email: supremecurehome@gmail.com Or supremecurehome@yahoo.com WhatsApp/Call number +2347087462033

    ReplyDelete