To show this, the authors embolized the uterine arteries of sheep using either their newly designed resorbable microspheres comprised of trisacryl-gelatin or traditional nonresorbable microspheres. At 7 days after embolization, an angiogram was performed to evaluate vascularity and the sheep were sacrificed to allow histologic evaluation of their arteries and uteri.
The study found that the resorbable microspheres disappeared and the arteries recanalized within 7 days in all of the sheep, something that was observed in only half of uterine arteries embolized with nonresorbable microspheres. Changes to the uterine tissue were observed to be similar. This exciting technology is yet to be tested in a large cohort, in a fibroid uterus, or in a human.
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Citation: Verret, V. et al. A Novel Resorbable Embolization Microsphere for Transient Uterine Artery Occlusion: A Comparative Study with Trisacryl-Gelatin Microspheres in the Sheep Model. Journal of Vascular and Interventional Radiology (2014)
Post author: Amish Patel, MD